HMM Summary Page: TIGR03660

FunctionT1SS-143 repeat domain
Trusted Cutoff66.05
Domain Trusted Cutoff66.05
Noise Cutoff52.75
Domain Noise Cutoff52.75
Isology Typedomain
HMM Length143
Mainrole CategoryCellular processes
Subrole CategoryPathogenesis
AuthorHaft DH
Entry DateSep 22 2008 12:24PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents a domain of about 143 amino acids that may occur singly or in up to 23 tandem repeats in very large proteins in the genus Vibrio, and in related species such as Legionella pneumophila, Photobacterium profundum, Rhodopseudomonas palustris, Shewanella pealeana, and Aeromonas hydrophila. Proteins with these domains represent a subset of a broader set of proteins with a particular signal for type 1 secretion, consisting of several glycine-rich repeats modeled by PF00353, followed by a C-terminal domain modeled by TIGR03661. Proteins with this domain tend to share several properties with the RtxA (Repeats in Toxin) protein of Vibrio cholerae, including a large size often containing tandemly repeated domains and a C-terminal signal for type 1 secretion.