| Accession | TIGR03656 |
| Name | IsdC |
| Function | heme uptake protein IsdC |
| Gene Symbol | isdC |
| Trusted Cutoff | 155.85 |
| Domain Trusted Cutoff | 155.85 |
| Noise Cutoff | 153.85 |
| Domain Noise Cutoff | 153.85 |
| Isology Type | equivalog |
| HMM Length | 219 |
| Gene Ontology Term | GO:0020037: heme binding molecular_function |
| Author | Selengut J |
| Entry Date | Sep 3 2008 11:07AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Isd proteins are iron-regulated surface proteins found in Bacillus, Staphylococcus and Listeria species and are responsible for heme scavenging from hemoproteins [1]. The IsdC protein consists of an N-terminal hydrophobic signal sequence, a central NEAT (NEAr Transporter, PF05031) domain which confers the ability to bind heme [2] and a C-terminal SrtB processing signal which targets the protein to the cell wall [3]. IsdC is believed to make a direct contact with, and transfer heme to, the heme-binding component (IsdE) of an ABC transporter in the cytoplasmic membrane, and to receive heme from other NEAT-containing heme-binding proteins also localized in the cell wall. |
| References | RN [1]
RM PMID:18676371
RT Demonstration of the iron-regulated surface determinant heme transfer pathway in Staphylococcus aureus.
RA Muryoi N, Tiedemann MT, Pluym M, Cheung J, Heinrichs DE, Stillman MJ
RL J Biol Chem. 2008 Aug 1.
RN [2]
RM PMID:18715872
RT The IsdC protein from staphylococcus aureus uses a flexible binding pocket to capture heme.
RA Villareal VA, Pilpa RM, Robson SA, Fadeev EA, Clubb RT
RL J Biol Chem. 2008 Aug 20.
RN [3]
RM PMID:17012401
RT Surface protein IsdC and Sortase B are required for heme-iron scavenging of Bacillus anthracis.
RA Maresso AW, Chapa TJ, Schneewind O
RL J Bacteriol. 2006 Dec;188(23):8145-52. Epub 2006 Sep 29. |
| Genome Property | GenProp0828: heme uptake system, NEAT-domain mediated (HMM) |
