HMM Summary Page: TIGR03652

Functioniron-sulfur cluster repair di-iron protein
Gene Symbolric
Trusted Cutoff204.70
Domain Trusted Cutoff204.70
Noise Cutoff99.10
Domain Noise Cutoff99.10
Isology Typeequivalog
HMM Length216
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryOther
Gene Ontology TermGO:0005506: iron ion binding molecular_function
GO:0030091: protein repair biological_process
GO:0051186: cofactor metabolic process biological_process
AuthorHaft DH
Entry DateAug 27 2008 4:12PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family, designated variously as YftE, NorA, DrnN, and NipC, are di-iron proteins involved in the repair of iron-sulfur clusters. Previously assigned names reflect pleiotropic effects of damage from NO or other oxidative stress when this protein is mutated. The suggested name now is RIC, for Repair of Iron Centers.
ReferencesRN [1] RM PMID:18203837 RT Widespread distribution in pathogenic bacteria of di-iron proteins that repair oxidative and nitrosative damage to iron-sulfur centers. RA Overton TW, Justino MC, Li Y, Baptista JM, Melo AM, Cole JA, Saraiva LM RL J Bacteriol. 2008 Mar;190(6):2004-13.