HMM Summary Page: TIGR03641

FunctionCRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP
Gene Symbolcas1b
Trusted Cutoff304.10
Domain Trusted Cutoff304.10
Noise Cutoff213.65
Domain Noise Cutoff213.65
Isology Typeexception
HMM Length324
AuthorHaft DH
Entry DateJul 2 2008 11:20AM
Last ModifiedFeb 14 2011 3:27PM
CommentThe CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.
ReferencesRN [1] RM PMID:16292354 RT A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes. RA Haft DH, Selengut J, Mongodin EF, Nelson KE RL PLoS Comput Biol. 2005 Nov;1(6):e60. Epub 2005 Nov 11.