HMM Summary Page: TIGR03621

Functionprobable F420-dependent oxidoreductase, MSMEG_2516 family
Trusted Cutoff213.15
Domain Trusted Cutoff213.15
Noise Cutoff163.05
Domain Noise Cutoff163.05
Isology Typesubfamily
HMM Length295
Mainrole CategoryUnknown function
Subrole CategoryEnzymes of unknown specificity
Gene Ontology TermGO:0008150: biological_process biological_process
GO:0016491: oxidoreductase activity molecular_function
AuthorHaft DH
Entry DateJun 13 2008 1:32PM
Last ModifiedFeb 14 2011 3:27PM
CommentCoenzyme F420 is produced by methanogenic archaea, a number of the Actinomycetes (including Mycobacterium tuberculosis), and rare members of other lineages. The resulting information-rich phylogenetic profile identifies candidate F420-dependent oxidoreductases within the family of luciferase-like enzymes (PF00296), where the species range for the subfamily encompasses many F420-positive genomes without straying beyond. This family is uncharacterized, and named for member MSMEG_2516 from Mycobacterium smegmatis.
ReferencesRN [1] RM PMID:20675471 RT Unexpected abundance of coenzyme F(420)-dependent enzymes in Mycobacterium tuberculosis and other actinobacteria. RA Selengut JD, Haft DH RL J Bacteriol. 2010 Nov;192(21):5788-98.
Genome PropertyGenProp0002: coenzyme F420 utilization (HMM)