HMM Summary Page: TIGR03606

Functiondehydrogenase, PQQ-dependent, s-GDH family
Trusted Cutoff434.55
Domain Trusted Cutoff434.55
Noise Cutoff198.30
Domain Noise Cutoff198.30
Isology Typesubfamily
HMM Length454
AuthorHaft DH
Entry DateMay 5 2008 10:10AM
Last ModifiedFeb 14 2011 3:27PM
CommentPQQ, or pyrroloquinoline-quinone, serves as a cofactor for a number of sugar and alcohol dehydrogenases in a limited number of bacterial species. Most characterized PQQ-dependent enzymes have multiple repeats of a sequence region described by PF01011 (PQQ enzyme repeat), but this protein family in unusual in lacking that repeat. Below the noise cutoff are related proteins mostly from species that lack PQQ biosynthesis.
ReferencesRN [1] RM PMID:10366508 RT The 1.7 A crystal structure of the apo form of the soluble quinoprotein glucose dehydrogenase from Acinetobacter calcoaceticus reveals a novel internal conserved sequence repeat. RA Oubrie A, Rozeboom HJ, Kalk KH, Duine JA, Dijkstra BW RL J Mol Biol. 1999 Jun 4;289(2):319-33.