HMM Summary Page: TIGR03605

FunctionSagB-type dehydrogenase domain
Trusted Cutoff78.40
Domain Trusted Cutoff78.40
Noise Cutoff47.35
Domain Noise Cutoff47.35
Isology Typedomain
HMM Length173
AuthorHaft DH
Entry DateMay 5 2008 9:25AM
Last ModifiedFeb 14 2011 3:27PM
CommentSagB of Sterptococcus pyogenes participates in the maturation of streptolysin S from a ribosomally produced precursor polypeptide. Chemically similar systems operate on highly diverse sets of bacteriocin precursors in numerous other bacteria. This model describes a domain within SgaB and homologous regions from other proteins, many of which appear to be involved in biosynthesis of secondary metabolites. While some substrates may be intermediates in non-ribosomal peptide syntheses, others are involved in heterocycle-containing bacteriocin biosynthesis, and can be found near SgaC-like (see TIGR03603, cyclodehydratase) and SgaD-like (see TIGR03604, "docking") proteins. Members of this domain family are heterogeneous in length, as many have a partial second copy of the domain represented here. The incomplete second domain scores below the cutoffs to this model in most cases.
ReferencesRN [1] RM PMID:18375757 RT Discovery of a widely distributed toxin biosynthetic gene cluster. RA Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE RL Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5879-84.
Genome PropertyGenProp0807: bacteriocin system, heterocycle biosynthesis group (HMM)