| Accession | TIGR03604 |
| Name | TOMM_cyclo_SagD |
| Function | thiazole/oxazole-forming peptide maturase, SagD family component |
| Trusted Cutoff | 219.25 |
| Domain Trusted Cutoff | 219.25 |
| Noise Cutoff | 94.10 |
| Domain Noise Cutoff | 94.10 |
| Isology Type | subfamily_domain |
| HMM Length | 377 |
| Author | Haft DH |
| Entry Date | May 2 2008 3:04PM |
| Last Modified | Aug 14 2012 2:34PM |
| Comment | Members of this protein family include enzymes related to SagD, previously referred to as a scaffold or docking protein involved in the biosynthesis of streptolysin S in Streptococcus pyogenes from the protoxin polypeptide (product of the sagA gene). Newer evidence describes an enzymatic activity, an ATP-dependent cyclodehydration reaction, previously ascribed to the SagC component. This protein family serves as a marker for widely distributed prokaryotic systems for making a general class of heterocycle-containing bacteriocins. |
| References | RN [1]
RM PMID:22522320
RT YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations.
RA Dunbar KL, Melby JO, Mitchell DA
RL Nat Chem Biol. 2012 Apr 22;8(6):569-75.
RN [2]
RM PMID:18375757
RT Discovery of a widely distributed toxin biosynthetic gene cluster.
RA Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE
RL Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5879-84. |
| Genome Property | GenProp0807: bacteriocin system, heterocycle biosynthesis group (HMM) |
