HMM Summary Page: TIGR03603

Functionthiazole/oxazole-forming peptide maturase, SagC family component
Trusted Cutoff187.65
Domain Trusted Cutoff187.65
Noise Cutoff55.20
Domain Noise Cutoff55.20
Isology Typesubfamily
EC Number6.3.-.-
HMM Length319
Mainrole CategoryCellular processes
Subrole CategoryPathogenesis
Gene Ontology TermGO:0016882: cyclo-ligase activity molecular_function
GO:0030152: bacteriocin biosynthetic process biological_process
AuthorHaft DH
Entry DateMay 2 2008 12:22PM
Last ModifiedAug 14 2012 2:44PM
CommentMembers of this protein family include enzymes related to SagC, a protein involved in thiazole/oxazole cyclodehydration modifications during biosynthesis of streptolysin S in Streptococcus pyogenes from the protoxin polypeptide (product of the sagA gene). Recent evidence suggests that the YcaO/SagD-like component, not this component, performs an ATP-dependent cyclodehydration. This protein family serves as a marker for widely distributed prokaryotic systems for making a general class of heterocycle-containing bacteriocins. Note that this model does not find all possible examples of bacteriocin biosynthesis cyclodehydratases, an in particular misses the E. coli plasmid protein McbB of microcin B17 biosynthesis.
ReferencesRN [1] RM PMID:22522320 RT YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations. RA Dunbar KL, Melby JO, Mitchell DA RL Nat Chem Biol. 2012 Apr 22;8(6):569-75. RN [2] RM PMID:18375757 RT Discovery of a widely distributed toxin biosynthetic gene cluster. RA Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE RL Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5879-84.
Genome PropertyGenProp0807: bacteriocin system, heterocycle biosynthesis group (HMM)