HMM Summary Page: TIGR03594

Functionribosome-associated GTPase EngA
Gene SymbolengA
Trusted Cutoff306.70
Domain Trusted Cutoff306.70
Noise Cutoff230.20
Domain Noise Cutoff230.20
Isology Typeequivalog
HMM Length432
Mainrole CategoryProtein synthesis
Subrole CategoryOther
Gene Ontology TermGO:0003924: GTPase activity molecular_function
GO:0005525: GTP binding molecular_function
GO:0005737: cytoplasm cellular_component
GO:0042254: ribosome biogenesis biological_process
GO:0043022: ribosome binding molecular_function
AuthorHaft DH
Entry DateApr 15 2008 11:32AM
Last ModifiedFeb 14 2011 3:27PM
CommentEngA (YfgK, Der) is a ribosome-associated essential GTPase with a duplication of its GTP-binding domain. It is broadly to universally distributed among bacteria. It appears to function in ribosome biogenesis or stability.
ReferencesRN [1] RM PMID:16963571 RT Cooperative and critical roles for both G domains in the GTPase activity and cellular function of ribosome-associated Escherichia coli EngA. RA Bharat A, Jiang M, Sullivan SM, Maddock JR, Brown ED RL J Bacteriol. 2006 Nov;188(22):7992-6. RN [2] RM PMID:17905831 RT Functional analysis of the GTPases EngA and YhbZ encoded by Salmonella typhimurium. RA Lamb HK, Thompson P, Elliott C, Charles IG, Richards J, Lockyer M, Watkins N, Nichols C, Stammers DK, Bagshaw CR, Cooper A, Hawkins AR RL Protein Sci. 2007 Nov;16(11):2391-402.
Genome PropertyGenProp0802: ribosome biogenesis proteins, bacteria (HMM)
GenProp0799: bacterial core gene set, exactly 1 per genome (HMM)