| Accession | TIGR03593 |
| Name | yidC_nterm |
| Function | membrane protein insertase, YidC/Oxa1 family, N-terminal domain |
| Gene Symbol | yidC |
| Trusted Cutoff | 58.25 |
| Domain Trusted Cutoff | 58.25 |
| Noise Cutoff | 34.30 |
| Domain Noise Cutoff | 34.30 |
| Isology Type | equivalog_domain |
| HMM Length | 363 |
| Mainrole Category | Protein fate |
| Subrole Category | Protein and peptide secretion and trafficking |
| Gene Ontology Term | GO:0003674: molecular_function molecular_function |
| | GO:0051205: protein insertion into membrane biological_process |
| Author | Haft DH |
| Entry Date | Apr 14 2008 11:47AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Essentially all bacteria have a member of the YidC family, whose C-terminal domain is modeled by TIGR03592. The two copies are found in endospore-forming bacteria such as Bacillus subtilis appear redundant during vegetative growth, although the member designated spoIIIJ (stage III sporulation protein J) has a distinct role in spore formation. YidC, its mitochondrial homolog Oxa1, and its chloroplast homolog direct insertion into the bacterial/organellar inner (or only) membrane. This model describes an N-terminal sequence region, including a large periplasmic domain lacking in YidC members from Gram-positive species. The multifunctional YidC protein acts both with and independently of the Sec system. |
| References | RN [1]
RM PMID:18259071
RT Purification, crystallization and preliminary structural characterization of the periplasmic domain P1 of the Escherichia coli membrane-protein insertase YidC.
RA Ravaud S, Wild K, Sinning I
RL Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Feb 1;64(Pt 2):144-8.
RN [2]
RM PMID:18054957
RT Projection structure of yidC: a conserved mediator of membrane protein assembly.
RA Lotz M, Haase W, Kuhlbrandt W, Collinson I
RL J Mol Biol. 2008 Jan 25;375(4):901-7. |
| Genome Property | GenProp0209: Sec system preprotein translocase (HMM) |
