HMM Summary Page: TIGR03593

Functionmembrane protein insertase, YidC/Oxa1 family, N-terminal domain
Gene SymbolyidC
Trusted Cutoff58.25
Domain Trusted Cutoff58.25
Noise Cutoff34.30
Domain Noise Cutoff34.30
Isology Typeequivalog_domain
HMM Length363
Mainrole CategoryProtein fate
Subrole CategoryProtein and peptide secretion and trafficking
Gene Ontology TermGO:0003674: molecular_function molecular_function
GO:0051205: protein insertion into membrane biological_process
AuthorHaft DH
Entry DateApr 14 2008 11:47AM
Last ModifiedFeb 14 2011 3:27PM
CommentEssentially all bacteria have a member of the YidC family, whose C-terminal domain is modeled by TIGR03592. The two copies are found in endospore-forming bacteria such as Bacillus subtilis appear redundant during vegetative growth, although the member designated spoIIIJ (stage III sporulation protein J) has a distinct role in spore formation. YidC, its mitochondrial homolog Oxa1, and its chloroplast homolog direct insertion into the bacterial/organellar inner (or only) membrane. This model describes an N-terminal sequence region, including a large periplasmic domain lacking in YidC members from Gram-positive species. The multifunctional YidC protein acts both with and independently of the Sec system.
ReferencesRN [1] RM PMID:18259071 RT Purification, crystallization and preliminary structural characterization of the periplasmic domain P1 of the Escherichia coli membrane-protein insertase YidC. RA Ravaud S, Wild K, Sinning I RL Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Feb 1;64(Pt 2):144-8. RN [2] RM PMID:18054957 RT Projection structure of yidC: a conserved mediator of membrane protein assembly. RA Lotz M, Haase W, Kuhlbrandt W, Collinson I RL J Mol Biol. 2008 Jan 25;375(4):901-7.
Genome PropertyGenProp0209: Sec system preprotein translocase (HMM)