HMM Summary Page: TIGR03588

FunctionUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase
Gene SymbolpseC
Trusted Cutoff423.50
Domain Trusted Cutoff423.50
Noise Cutoff419.20
Domain Noise Cutoff419.20
Isology Typeequivalog
EC Number2.6.1.92
HMM Length380
AuthorSelengut J
Entry DateApr 9 2008 2:23PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family of enzymes are aminotransferases of the PF01041 family involved in the biosynthesis of pseudaminic acid [1,2,3]. They convert UDP-4-keto-6-deoxy-N-acetylglucosamine into UDP-4-amino-4,6-dideoxy-N-acetylgalactose. Pseudaminic acid has a role in surface polysaccharide in Pseudomonas as well as in the modification of flagellin in Campylobacter and Helicobacter species [4].
ReferencesRN [1] RM PMID:16421095 RT Structural and functional characterization of PseC, an aminotransferase involved in the biosynthesis of pseudaminic acid, an essential flagellar modification in Helicobacter pylori. RA Schoenhofen IC, Lunin VV, Julien JP, Li Y, Ajamian E, Matte A, Cygler M, Brisson JR, Aubry A, Logan SM, Bhatia S, Wakarchuk WW, Young NM RL J Biol Chem. 2006 Mar 31;281(13):8907-16. Epub 2006 Jan 18. RN [2] RM PMID:16286454 RT Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways. RA Schoenhofen IC, McNally DJ, Vinogradov E, Whitfield D, Young NM, Dick S, Wakarchuk WW, Brisson JR, Logan SM RL J Biol Chem. 2006 Jan 13;281(2):723-32. Epub 2005 Nov 11. RN [3] RM PMID:15790564 RT Biochemical characterization of the Campylobacter jejuni Cj1294, a novel UDP-4-keto-6-deoxy-GlcNAc aminotransferase that generates UDP-4-amino-4,6-dideoxy-GalNAc. RA Obhi RK, Creuzenet C RL J Biol Chem. 2005 May 27;280(21):20902-8. Epub 2005 Mar 24. RN [4] RM PMID:16684771 RT Functional characterization of the flagellar glycosylation locus in Campylobacter jejuni 81-176 using a focused metabolomics approach. RA McNally DJ, Hui JP, Aubry AJ, Mui KK, Guerry P, Brisson JR, Logan SM, Soo EC RL J Biol Chem. 2006 Jul 7;281(27):18489-98. Epub 2006 May 9.
Genome PropertyGenProp0796: CMP-pseudaminic acid biosynthesis from UDP-N-acetylglucosamine (HMM)