HMM Summary Page: TIGR03585

FunctionUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase
Gene SymbolpseH
Trusted Cutoff93.10
Domain Trusted Cutoff93.10
Noise Cutoff81.60
Domain Noise Cutoff81.60
Isology Typeequivalog
EC Number2.3.1.202
HMM Length156
AuthorSelengut J, Haft DH
Entry DateApr 8 2008 5:17PM
Last ModifiedJan 27 2014 11:21AM
CommentSequences in this family are members of the PF00583 (GNAT) superfamily of acetyltransferases and are proposed to perform a N-acetylation step in the process of pseudaminic acid biosynthesis in Campylobacter species [1]. This gene is commonly observed in apparent operons with other genes responsible for the biosynthesis of pseudaminic acid and as a component of flagellar and exopolysaccharide biosynthesis loci. Significantly, many genomes containing other components of this pathway lack this gene, indicating that some other N-acetyl transferases may be incolved and/or the step is optional, resulting in a non-acetylated pseudaminic acid variant sugar.
ReferencesRN [1] RM PMID:19483088 RT Structural and functional analysis of Campylobacter jejuni PseG: a udp-sugar hydrolase from the pseudaminic acid biosynthetic pathway. RA Rangarajan ES, Proteau A, Cui Q, Logan SM, Potetinova Z, Whitfield D, Purisima EO, Cygler M, Matte A, Sulea T, Schoenhofen IC RL J Biol Chem. 2009 Jul 31;284(31):20989-1000. doi: 10.1074/jbc.M109.012351. RN [2] RM PMID:16684771 RT Functional characterization of the flagellar glycosylation locus in Campylobacter jejuni 81-176 using a focused metabolomics approach. RA McNally DJ, Hui JP, Aubry AJ, Mui KK, Guerry P, Brisson JR, Logan SM, Soo EC RL J Biol Chem. 2006 Jul 7;281(27):18489-98. Epub 2006 May 9.
Genome PropertyGenProp0796: CMP-pseudaminic acid biosynthesis from UDP-N-acetylglucosamine (HMM)