HMM Summary Page: TIGR03584

Functionpseudaminic acid cytidylyltransferase
Gene SymbolpseF
Trusted Cutoff205.70
Domain Trusted Cutoff205.70
Noise Cutoff199.80
Domain Noise Cutoff199.80
Isology Typeequivalog
EC Number2.7.7.81
HMM Length222
AuthorSelengut J
Entry DateApr 8 2008 5:04PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe sequences in this family include the PF02348 (cytidyltransferase) domain and are homologous to the NeuA protein responsible for the transfer of CMP to neuraminic acid. According to [1], this gene is responsible for the transfer of CMP to the structurally related sugar, pseudaminic acid which is observed as a component of sugar modifications of flagellin in Campylobacter species. This gene is commonly observed in apparent operons with other genes responsible for the biosynthesis of pseudaminic acid and as a component of flagellar and exopolysaccharide biosynthesis loci.
ReferencesRN [1] RM PMID:16684771 RT Functional characterization of the flagellar glycosylation locus in Campylobacter jejuni 81-176 using a focused metabolomics approach. RA McNally DJ, Hui JP, Aubry AJ, Mui KK, Guerry P, Brisson JR, Logan SM, Soo EC RL J Biol Chem. 2006 Jul 7;281(27):18489-98. Epub 2006 May 9.
Genome PropertyGenProp0796: CMP-pseudaminic acid biosynthesis from UDP-N-acetylglucosamine (HMM)