HMM Summary Page: TIGR03576

Functionpyridoxal phosphate enzyme, MJ0158 family
Trusted Cutoff304.45
Domain Trusted Cutoff304.45
Noise Cutoff96.10
Domain Noise Cutoff96.10
Isology Typehypoth_equivalog
HMM Length346
Mainrole CategoryUnknown function
Subrole CategoryEnzymes of unknown specificity
AuthorHaft DH
Entry DateApr 8 2008 9:40AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this archaeal protein family are pyridoxal phosphate enzymes of unknown function. Sequence similarity to SelA, a bacterial enzyme of selenocysteine biosynthesis, has led to some members being misannotated as functionally equivalent, but selenocysteine is made on tRNA in Archaea by a two-step process that does not involve a SelA homolog.
ReferencesRN [1] RM PMID:16201757 RT Structural and functional investigation of a putative archaeal selenocysteine synthase. RA Kaiser JT, Gromadski K, Rother M, Engelhardt H, Rodnina MV, Wahl MC RL Biochemistry. 2005 Oct 11;44(40):13315-27.