| Accession | TIGR03575 |
| Name | selen_PSTK_euk |
| Function | L-seryl-tRNA(Sec) kinase |
| Trusted Cutoff | 382.35 |
| Domain Trusted Cutoff | 382.35 |
| Noise Cutoff | 100.60 |
| Domain Noise Cutoff | 100.60 |
| Isology Type | equivalog |
| EC Number | 2.7.1.164 |
| HMM Length | 340 |
| Gene Ontology Term | GO:0016260: selenocysteine biosynthetic process biological_process |
| | GO:0016773: phosphotransferase activity, alcohol group as acceptor molecular_function |
| Author | Haft DH |
| Entry Date | Apr 7 2008 4:49PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this protein are L-seryl-tRNA(Sec) kinase. This enzyme is part of a two-step pathway in Eukaryota and Archaea for performing selenocysteine biosynthesis by changing serine misacylated on selenocysteine-tRNA to selenocysteine. This enzyme performs the first step, phosphorylation of the OH group of the serine side chain. This family represents eukaryotic proteins with this activity. |
| References | RN [1]
RM PMID:15317934
RT Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase.
RA Carlson BA, Xu XM, Kryukov GV, Rao M, Berry MJ, Gladyshev VN, Hatfield DL
RL Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12848-53. |
