HMM Summary Page: TIGR03575

FunctionL-seryl-tRNA(Sec) kinase
Trusted Cutoff382.35
Domain Trusted Cutoff382.35
Noise Cutoff100.60
Domain Noise Cutoff100.60
Isology Typeequivalog
EC Number2.7.1.164
HMM Length340
Gene Ontology TermGO:0016260: selenocysteine biosynthetic process biological_process
GO:0016773: phosphotransferase activity, alcohol group as acceptor molecular_function
AuthorHaft DH
Entry DateApr 7 2008 4:49PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein are L-seryl-tRNA(Sec) kinase. This enzyme is part of a two-step pathway in Eukaryota and Archaea for performing selenocysteine biosynthesis by changing serine misacylated on selenocysteine-tRNA to selenocysteine. This enzyme performs the first step, phosphorylation of the OH group of the serine side chain. This family represents eukaryotic proteins with this activity.
ReferencesRN [1] RM PMID:15317934 RT Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase. RA Carlson BA, Xu XM, Kryukov GV, Rao M, Berry MJ, Gladyshev VN, Hatfield DL RL Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12848-53.