HMM Summary Page: TIGR03574

FunctionL-seryl-tRNA(Sec) kinase
Gene SymbolpstK
Trusted Cutoff290.50
Domain Trusted Cutoff290.50
Noise Cutoff190.90
Domain Noise Cutoff190.90
Isology Typeequivalog
EC Number2.7.1.164
HMM Length249
Mainrole CategoryProtein synthesis
Subrole CategorytRNA aminoacylation
Gene Ontology TermGO:0016260: selenocysteine biosynthetic process biological_process
GO:0016773: phosphotransferase activity, alcohol group as acceptor molecular_function
AuthorHaft DH
Entry DateApr 7 2008 3:42PM
Last ModifiedDec 12 2011 11:11PM
CommentMembers of this protein are L-seryl-tRNA(Sec) kinase. This enzyme is part of a two-step pathway in Eukaryota and Archaea for performing selenocysteine biosynthesis by changing serine misacylated on selenocysteine-tRNA to selenocysteine. This enzyme performs the first step, phosphorylation of the OH group of the serine side chain. This family represents archaeal proteins with this activity.
ReferencesRN [1] RM PMID:18174226 RT Characterization and evolutionary history of an archaeal kinase involved in selenocysteinyl-tRNA formation. RA Sherrer RL, O'Donoghue P, Soll D RL Nucleic Acids Res. 2008 Mar;36(4):1247-59.
Genome PropertyGenProp0797: selenocysteinyl-tRNA, PSTK/SepSecS pathway (HMM)