HMM Summary Page: TIGR03568

FunctionUDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing
Gene SymbolneuC
Trusted Cutoff235.90
Domain Trusted Cutoff235.90
Noise Cutoff152.75
Domain Noise Cutoff152.75
Isology Typeequivalog
EC Number5.1.3.- 3.1.4.-
HMM Length365
AuthorSelengut J
Entry DateMar 19 2008 5:19PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family of enzymes catalyzes the combined epimerization and UDP-hydrolysis of UDP-N-acetylglucosamine to N-acetylmannosamine [1]. This is in contrast to the related enzyme WecB (TIGR00236) which retains the UDP moiety. NeuC acts in concert with NeuA and NeuB to synthesize CMP-N5-acetyl-neuraminate.
ReferencesRN [1] RM PMID:14729696 RT The NeuC protein of Escherichia coli K1 is a UDP N-acetylglucosamine 2-epimerase. RA Vann WF, Daines DA, Murkin AS, Tanner ME, Chaffin DO, Rubens CE, Vionnet J, Silver RP RL J Bacteriol. 2004 Feb;186(3):706-12.
Genome PropertyGenProp0793: CMP-N-acetylneuraminate biosynthesis from UDP-N-acetylglucosamine (HMM)