HMM Summary Page: TIGR03560

Functionprobable F420-dependent oxidoreductase, Rv1855c family
Trusted Cutoff231.40
Domain Trusted Cutoff231.40
Noise Cutoff231.00
Domain Noise Cutoff231.00
Isology Typesubfamily
HMM Length227
Mainrole CategoryUnknown function
Subrole CategoryEnzymes of unknown specificity
Gene Ontology TermGO:0008150: biological_process biological_process
GO:0016491: oxidoreductase activity molecular_function
AuthorHaft DH
Entry DateMar 13 2008 11:24AM
Last ModifiedFeb 14 2011 3:27PM
CommentCoenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (PF00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes one such subfamily, exemplified by Rv1855c from Mycobacterium tuberculosis.
ReferencesRN [1] RM PMID:20675471 RT Unexpected abundance of coenzyme F(420)-dependent enzymes in Mycobacterium tuberculosis and other actinobacteria. RA Selengut JD, Haft DH RL J Bacteriol. 2010 Nov;192(21):5788-98.
Genome PropertyGenProp0002: coenzyme F420 utilization (HMM)