| Accession | TIGR03553 |
| Name | F420_FbiB_CTERM |
| Function | F420 biosynthesis protein FbiB, C-terminal domain |
| Gene Symbol | fbiB |
| Trusted Cutoff | 249.55 |
| Domain Trusted Cutoff | 249.55 |
| Noise Cutoff | 77.75 |
| Domain Noise Cutoff | 77.75 |
| Isology Type | equivalog_domain |
| HMM Length | 194 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Other |
| Gene Ontology Term | GO:0009108: coenzyme biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Mar 3 2008 1:49PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Coenzyme F420 differs between the Archaea and the Actinobacteria, where the numbers of glutamate residues attached are 2 (Archaea) or 5-6 (Mycobacterium). The enzyme in the Archaea is homologous to the N-terminal domain of FbiB from Mycobacterium bovis, and is responsible for glutamate ligation. Therefore it seems likely that the C-terminal domain of FbiB, modeled by this HMM, is involved in additional glutamate ligation. |
| References | RN [1]
RM PMID:18260642
RT Identification and Characterization of the 2-Phospho-l-lactate Guanylyltransferase Involved in Coenzyme F420 Biosynthesis.
RA Grochowski LL, Xu H, White RH
RL Biochemistry. 2008 Feb 9
RN [2]
RM PMID:11717263
RT Use of transposon Tn5367 mutagenesis and a nitroimidazopyran-based selection system to demonstrate a requirement for fbiA and fbiB in coenzyme F(420) biosynthesis by Mycobacterium bovis BCG.
RA Choi KP, Bair TB, Bae YM, Daniels L
RL J Bacteriol. 2001 Dec;183(24):7058-66.
RN [3]
RM PMID:15215601
RT Identification and cloning of the gene involved in the final step of chlortetracycline biosynthesis in Streptomyces aureofaciens.
RA Nakano T, Miyake K, Endo H, Dairi T, Mizukami T, Katsumata R
RL Biosci Biotechnol Biochem. 2004 Jun;68(6):1345-52. |
| Genome Property | GenProp0791: coenzyme F420 biosynthesis (HMM) |
