HMM Summary Page: TIGR03550

Function7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofG subunit
Gene SymbolcofG
Trusted Cutoff213.35
Domain Trusted Cutoff213.35
Noise Cutoff106.85
Domain Noise Cutoff106.85
Isology Typeequivalog_domain
EC Number2.5.1.77
HMM Length322
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryOther
Gene Ontology TermGO:0009108: coenzyme biosynthetic process biological_process
AuthorHaft DH
Entry DateFeb 29 2008 2:25PM
Last ModifiedDec 12 2011 10:10PM
CommentThis model represents either a subunit or a domain, depending on whether or not the genes are fused, of a bifunctional protein that completes the synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin, or FO. FO is the chromophore of coenzyme F(420), involved in methanogenesis in methanogenic archaea but found in certain other lineages as well. The chromophore also occurs as a cofactor in DNA photolyases in Cyanobacteria.
ReferencesRN [1] RM PMID:14593448 RT Identification of the 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase required for coenzyme F(420) biosynthesis. RA Graham DE, Xu H, White RH RL Arch Microbiol. 2003 Dec;180(6):455-64. Epub 2003 Oct 31.
Genome PropertyGenProp0792: 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis (HMM)