HMM Summary Page: TIGR03549

FunctionYcaO domain protein
Trusted Cutoff900.00
Domain Trusted Cutoff900.00
Noise Cutoff800.00
Domain Noise Cutoff800.00
Isology Typehypoth_equivalog
HMM Length723
AuthorHaft DH
Entry DateFeb 29 2008 9:29AM
Last ModifiedAug 14 2012 3:33PM
CommentThis family consists of remarkably well-conserved proteins from gamma and beta Proteobacteria, heavily skewed towards organisms of marine environments. Its gene neighborhood is not conserved. This family has an OsmC-like N-terminal domain. It shares a YcaO domain, frequently associated with ATP-dependent cyclodehydration for peptide modification. The function is unknown. Fifteen of the first sixteen members of this family are from selenouridine-positive genomes, but this correlation may not be meaningful.
ReferencesRN [1] RM PMID:22522320 RT YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations. RA Dunbar KL, Melby JO, Mitchell DA RL Nat Chem Biol. 2012 Apr 22;8(6):569-75. doi: 10.1038/nchembio.944.