HMM Summary Page: TIGR03547

Functionmutatrotase, YjhT family
Trusted Cutoff256.35
Domain Trusted Cutoff256.35
Noise Cutoff156.00
Domain Noise Cutoff156.00
Isology Typesubfamily
EC Number5.1.-.-
HMM Length346
AuthorHaft DH
Entry DateFeb 26 2008 10:12AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family contain multiple copies of the beta-propeller-forming Kelch repeat. All are full-length homologs to YjhT of Escherichia coli, which has been identified as a mutarotase for sialic acid. This protein improves bacterial ability to obtain host sialic acid, and thus serves as a virulence factor. Some bacteria carry what appears to be a cyclically permuted homolog of this protein.
ReferencesRN [1] RM PMID:18063573 RT Sialic Acid Mutarotation Is Catalyzed by the Escherichia coli {beta}-Propeller Protein YjhT. RA Severi E, Muller A, Potts JR, Leech A, Williamson D, Wilson KS, Thomas GH RL J Biol Chem. 2008 Feb 22;283(8):4841-9.