HMM Summary Page: TIGR03547
| Accession | TIGR03547 |
| Name | muta_rot_YjhT |
| Function | mutatrotase, YjhT family |
| Trusted Cutoff | 256.35 |
| Domain Trusted Cutoff | 256.35 |
| Noise Cutoff | 156.00 |
| Domain Noise Cutoff | 156.00 |
| Isology Type | subfamily |
| EC Number | 5.1.-.- |
| HMM Length | 346 |
| Author | Haft DH |
| Entry Date | Feb 26 2008 10:12AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this protein family contain multiple copies of the beta-propeller-forming Kelch repeat. All are full-length homologs to YjhT of Escherichia coli, which has been identified as a mutarotase for sialic acid. This protein improves bacterial ability to obtain host sialic acid, and thus serves as a virulence factor. Some bacteria carry what appears to be a cyclically permuted homolog of this protein. |
| References | RN [1] RM PMID:18063573 RT Sialic Acid Mutarotation Is Catalyzed by the Escherichia coli {beta}-Propeller Protein YjhT. RA Severi E, Muller A, Potts JR, Leech A, Williamson D, Wilson KS, Thomas GH RL J Biol Chem. 2008 Feb 22;283(8):4841-9. |