| Accession | TIGR03534 |
| Name | RF_mod_PrmC |
| Function | protein-(glutamine-N5) methyltransferase, release factor-specific |
| Gene Symbol | prmC |
| Trusted Cutoff | 199.10 |
| Domain Trusted Cutoff | 199.10 |
| Noise Cutoff | 198.70 |
| Domain Noise Cutoff | 198.70 |
| Isology Type | equivalog |
| EC Number | 2.1.1.- |
| HMM Length | 253 |
| Mainrole Category | Protein fate |
| Subrole Category | Protein modification and repair |
| Gene Ontology Term | GO:0006412: translation biological_process |
| | GO:0008757: S-adenosylmethionine-dependent methyltransferase activity molecular_function |
| | GO:0018364: peptidyl-glutamine methylation biological_process |
| Author | Haft DH |
| Entry Date | Jan 26 2008 5:10PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. |
| References | RN [1]
RM PMID:11847124
RT The hemK gene in Escherichia coli encodes the N(5)-glutamine methyltransferase that modifies peptide release factors.
RA Heurgue-Hamard V, Champ S, Engstrom A, Ehrenberg M, Buckingham RH
RL EMBO J. 2002 Feb 15;21(4):769-78. |
| Genome Property | GenProp0746: translation termination, bacterial (HMM) |
