HMM Summary Page: TIGR03534

Functionprotein-(glutamine-N5) methyltransferase, release factor-specific
Gene SymbolprmC
Trusted Cutoff199.10
Domain Trusted Cutoff199.10
Noise Cutoff198.70
Domain Noise Cutoff198.70
Isology Typeequivalog
EC Number2.1.1.-
HMM Length253
Mainrole CategoryProtein fate
Subrole CategoryProtein modification and repair
Gene Ontology TermGO:0006412: translation biological_process
GO:0008757: S-adenosylmethionine-dependent methyltransferase activity molecular_function
GO:0018364: peptidyl-glutamine methylation biological_process
AuthorHaft DH
Entry DateJan 26 2008 5:10PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3.
ReferencesRN [1] RM PMID:11847124 RT The hemK gene in Escherichia coli encodes the N(5)-glutamine methyltransferase that modifies peptide release factors. RA Heurgue-Hamard V, Champ S, Engstrom A, Ehrenberg M, Buckingham RH RL EMBO J. 2002 Feb 15;21(4):769-78.
Genome PropertyGenProp0746: translation termination, bacterial (HMM)