HMM Summary Page: TIGR03526

Functionputative selenium metabolism hydrolase
Trusted Cutoff321.50
Domain Trusted Cutoff321.50
Noise Cutoff153.20
Domain Noise Cutoff153.20
Isology Typehypoth_equivalog
HMM Length395
AuthorHaft DH
Entry DateDec 20 2007 9:59AM
Last ModifiedMar 25 2011 9:20AM
CommentSelD, selenophosphate synthase, is the selenium donor protein for both selenocysteine and selenouridine biosynthesis systems, but it occurs also in a few prokaryotes that have neither of those pathways. The method of partial phylogenetic profiling [1], starting from such orphan-selD genomes, identifies this protein as one of those most strongly correlated to SelD occurrence. Its distribution is also well correlated with that of family TIGR03309, a putative accessory protein of labile selenium (non-selenocysteine) enzyme maturation. This family includes the uncharacterized YgeY of Escherichia coli, and belongs to a larger family of metalloenzymes in which some are known peptidases, others enzymes of different types.
ReferencesRN [1] RM PMID: 16930487 RT Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic. RA Haft DH, Paulsen IT, Ward N, Selengut JD RL BMC Biol. 2006 Aug 24;4:29.
Genome PropertyGenProp0726: selenium-dependent molybdenum hydroxylase system (HMM)