HMM Summary Page: TIGR03505

FunctionFimV N-terminal domain
Gene SymbolfimV
Trusted Cutoff43.45
Domain Trusted Cutoff43.45
Noise Cutoff42.30
Domain Noise Cutoff42.30
Isology Typeequivalog_domain
HMM Length74
AuthorHaft DH
Entry DateNov 27 2007 1:20PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis region is found at, or about 200 amino acids from, the N-terminus of FimV from Pseudomonas aeruginosa, TspA of Neisseria meningitidis, and related proteins. Disruption of FimV blocks twitching motility from type IV pili; Semmler, et al. suggest a role for this family in peptidoglycan layer remodelling required by type IV fimbrial systems. Most but not all members of this protein family have a C-terminal region recognized by TIGR03504. In between is a highly variable, often repeat-filled region rich in the negatively charged amino acids Asp and Glu.
ReferencesRN [1] RM PMID:10846211 RT Identification of a novel gene, fimV, involved in twitching motility in Pseudomonas aeruginosa. RA Semmler AB, Whitchurch CB, Leech AJ, Mattick JS RL Microbiology. 2000 Jun;146 ( Pt 6):1321-32. RN [2] RM PMID:10377136 RT Identification and characterization of TspA, a major CD4(+) T-cell- and B-cell-stimulating Neisseria-specific antigen. RA Kizil G, Todd I, Atta M, Borriello SP, Ait-Tahar K, Ala'Aldeen DA RL Infect Immun. 1999 Jul;67(7):3533-41.