HMM Summary Page: TIGR03504

FunctionFimV C-terminal domain
Gene SymbolfimV
Trusted Cutoff30.65
Domain Trusted Cutoff30.65
Noise Cutoff23.45
Domain Noise Cutoff23.45
Isology Typehypoth_equivalog_domain
HMM Length44
AuthorHaft DH
Entry DateNov 27 2007 11:41AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein is found at the extreme C-terminus of FimV from Pseudomonas aeruginosa, and of TspA of Neisseria meningitidis. Disruption of the former blocks twitching motility from type IV pili; Semmler, et al. suggest a role in peptidoglycan layer remodelling required by type IV fimbrial systems.
ReferencesRN [1] RM PMID:10846211 RT Identification of a novel gene, fimV, involved in twitching motility in Pseudomonas aeruginosa. RA Semmler AB, Whitchurch CB, Leech AJ, Mattick JS RL Microbiology. 2000 Jun;146 ( Pt 6):1321-32. RN [2] RM PMID:10377136 RT Identification and characterization of TspA, a major CD4(+) T-cell- and B-cell-stimulating Neisseria-specific antigen. RA Kizil G, Todd I, Atta M, Borriello SP, Ait-Tahar K, Ala'Aldeen DA RL Infect Immun. 1999 Jul;67(7):3533-41.