HMM Summary Page: TIGR03465

Functionsqualene synthase HpnD
Gene SymbolhpnD
Trusted Cutoff278.60
Domain Trusted Cutoff278.60
Noise Cutoff251.35
Domain Noise Cutoff251.35
Isology Typeequivalog
EC Number2.5.1.21
HMM Length267
AuthorSelengut J
Entry DateAug 7 2007 11:06AM
Last ModifiedFeb 16 2011 9:52AM
CommentThe genes of this family are often found in the same genetic locus with squalene-hopene cyclase genes, and are never associated with genes for the metabolism of phytoene. In the organisms Zymomonas mobilis and Bradyrhizobium japonicum these genes have been characterized as squalene synthases (farnesyl-pyrophosphate ligases) [1]. Often, these genes appear in tandem with the HpnC gene which appears to have resulted from an ancient gene duplication event. Presumably these proteins form a heteromeric complex, but this has not yet been experimentally demonstrated.
ReferencesRN [1] RM PMID:9714766 RT Cloning of conserved genes from Zymomonas mobilis and Bradyrhizobium japonicum that function in the biosynthesis of hopanoid lipids. RA Perzl M, Reipen IG, Schmitz S, Poralla K, Sahm H, Sprenger GA, Kannenberg EL RL Biochim Biophys Acta. 1998 Jul 31;1393(1):108-18.
Genome PropertyGenProp0761: hopanoid lipid biosynthesis (HMM)