HMM Summary Page: TIGR03464

Functionsqualene synthase HpnC
Gene SymbolhpnC
Trusted Cutoff250.45
Domain Trusted Cutoff250.45
Noise Cutoff201.00
Domain Noise Cutoff201.00
Isology Typeequivalog
EC Number2.4.1.21
HMM Length267
AuthorSelengut J
Entry DateAug 7 2007 11:04AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family of genes are members of a superfamily (PF00494) of phytoene and squalene synthases which catalyze the head-t0-head condensation of polyisoprene pyrophosphates. The genes of this family are often found in the same genetic locus with squalene-hopene cyclase genes, and are never associated with genes for the metabolism of phytoene. In the organisms Zymomonas mobilis and Bradyrhizobium japonicum these genes have been characterized as squalene synthases (farnesyl-pyrophosphate ligases) [1]. Often, these genes appear in tandem with the HpnD gene which appears to have resulted from an ancient gene duplication event. Presumably these proteins form a heteromeric complex, but this has not yet been experimentally demonstrated.
ReferencesRN [1] RM PMID:9714766 RT Cloning of conserved genes from Zymomonas mobilis and Bradyrhizobium japonicum that function in the biosynthesis of hopanoid lipids. RA Perzl M, Reipen IG, Schmitz S, Poralla K, Sahm H, Sprenger GA, Kannenberg EL RL Biochim Biophys Acta. 1998 Jul 31;1393(1):108-18.
Genome PropertyGenProp0761: hopanoid lipid biosynthesis (HMM)