HMM Summary Page: TIGR03464
| Accession | TIGR03464 |
| Name | HpnC |
| Function | squalene synthase HpnC |
| Gene Symbol | hpnC |
| Trusted Cutoff | 250.45 |
| Domain Trusted Cutoff | 250.45 |
| Noise Cutoff | 201.00 |
| Domain Noise Cutoff | 201.00 |
| Isology Type | equivalog |
| EC Number | 2.4.1.21 |
| HMM Length | 267 |
| Author | Selengut J |
| Entry Date | Aug 7 2007 11:04AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This family of genes are members of a superfamily (PF00494) of phytoene and squalene synthases which catalyze the head-t0-head condensation of polyisoprene pyrophosphates. The genes of this family are often found in the same genetic locus with squalene-hopene cyclase genes, and are never associated with genes for the metabolism of phytoene. In the organisms Zymomonas mobilis and Bradyrhizobium japonicum these genes have been characterized as squalene synthases (farnesyl-pyrophosphate ligases) [1]. Often, these genes appear in tandem with the HpnD gene which appears to have resulted from an ancient gene duplication event. Presumably these proteins form a heteromeric complex, but this has not yet been experimentally demonstrated. |
| References | RN [1] RM PMID:9714766 RT Cloning of conserved genes from Zymomonas mobilis and Bradyrhizobium japonicum that function in the biosynthesis of hopanoid lipids. RA Perzl M, Reipen IG, Schmitz S, Poralla K, Sahm H, Sprenger GA, Kannenberg EL RL Biochim Biophys Acta. 1998 Jul 31;1393(1):108-18. |
| Genome Property | GenProp0761: hopanoid lipid biosynthesis (HMM) |