HMM Summary Page: TIGR03463

Function2,3-oxidosqualene cyclase
Trusted Cutoff851.00
Domain Trusted Cutoff851.00
Noise Cutoff850.75
Domain Noise Cutoff850.75
Isology Typesubfamily
EC Number5.4.99.8
HMM Length634
AuthorSelengut J
Entry DateAug 3 2007 4:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model identifies 2,3-oxidosqualene cyclases from Stigmatella aurantiaca which produces cycloartenol [1], and Gemmata obscuriglobus [2] and Methylococcus capsulatus [3] which each produce the closely related sterol, lanosterol.
ReferencesRN [1] RM PMID:12519197 RT Steroid biosynthesis in prokaryotes: identification of myxobacterial steroids and cloning of the first bacterial 2,3(S)-oxidosqualene cyclase from the myxobacterium Stigmatella aurantiaca. RA Bode HB, Zeggel B, Silakowski B, Wenzel SC, Reichenbach H, Muller R RL Mol Microbiol. 2003 Jan;47(2):471-81. RN [2] RM PMID:17567593 RT Lanosterol Biosynthesis in the Prokaryote Methylococcus capsulatus: Insight into the Evolution of Sterol Biosynthesis. RA Lamb DC, Jackson CJ, Warrilow AG, Manning NJ, Kelly DE, Kelly SL RL Mol Biol Evol. 2007 Jun 13 RN [3] RM PMID:6780348 RT Non-specific lanosterol and hopanoid biosynthesis be a cell-free system from the bacterium Methylococcus capsulatus. RA Rohmer M, Bouvier P, Ourisson G RL Eur J Biochem. 1980 Dec;112(3):557-60.