| Accession | TIGR03452 |
| Name | mycothione_red |
| Function | mycothione reductase |
| Gene Symbol | mtr |
| Trusted Cutoff | 635.65 |
| Domain Trusted Cutoff | 635.65 |
| Noise Cutoff | 411.55 |
| Domain Noise Cutoff | 411.55 |
| Isology Type | equivalog |
| EC Number | 1.8.1.15 |
| HMM Length | 452 |
| Gene Ontology Term | GO:0010126: mycothiol metabolic process biological_process |
| | GO:0050627: mycothione reductase activity molecular_function |
| Author | Haft DH |
| Entry Date | Jun 29 2007 11:47AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Mycothiol, a glutathione analog in Mycobacterium tuberculosis and related species, can form a disulfide-linked dimer called mycothione. This enzyme can reduce mycothione to regenerate two mycothiol molecules. The enzyme shows some sequence similarity to glutathione-disulfide reductase, trypanothione-disulfide reductase, and dihydrolipoamide dehydrogenase. The characterized protein from M. tuberculosis, a homodimer, has FAD as a cofactor, one per monomer, and uses NADPH as a substrate. |
| References | RN [1]
RM PMID:10512639
RT Expression, purification, and characterization of Mycobacterium tuberculosis mycothione reductase.
RA Patel MP, Blanchard JS
RL Biochemistry. 1999 Sep 7;38(36):11827-33. |
| Genome Property | GenProp0923: mycothiol system (HMM) |
