HMM Summary Page: TIGR03452

Functionmycothione reductase
Gene Symbolmtr
Trusted Cutoff635.65
Domain Trusted Cutoff635.65
Noise Cutoff411.55
Domain Noise Cutoff411.55
Isology Typeequivalog
EC Number1.8.1.15
HMM Length452
Gene Ontology TermGO:0010126: mycothiol metabolic process biological_process
GO:0050627: mycothione reductase activity molecular_function
AuthorHaft DH
Entry DateJun 29 2007 11:47AM
Last ModifiedFeb 14 2011 3:27PM
CommentMycothiol, a glutathione analog in Mycobacterium tuberculosis and related species, can form a disulfide-linked dimer called mycothione. This enzyme can reduce mycothione to regenerate two mycothiol molecules. The enzyme shows some sequence similarity to glutathione-disulfide reductase, trypanothione-disulfide reductase, and dihydrolipoamide dehydrogenase. The characterized protein from M. tuberculosis, a homodimer, has FAD as a cofactor, one per monomer, and uses NADPH as a substrate.
ReferencesRN [1] RM PMID:10512639 RT Expression, purification, and characterization of Mycobacterium tuberculosis mycothione reductase. RA Patel MP, Blanchard JS RL Biochemistry. 1999 Sep 7;38(36):11827-33.
Genome PropertyGenProp0923: mycothiol system (HMM)