HMM Summary Page: TIGR03451

FunctionS-(hydroxymethyl)mycothiol dehydrogenase
Trusted Cutoff512.90
Domain Trusted Cutoff512.90
Noise Cutoff512.15
Domain Noise Cutoff512.15
Isology Typeequivalog
EC Number1.1.1.306
HMM Length358
Mainrole CategoryCellular processes
Subrole CategoryDetoxification
Gene Ontology TermGO:0010127: mycothiol-dependent detoxification biological_process
GO:0050607: mycothiol-dependent formaldehyde dehydrogenase activity molecular_function
AuthorHaft DH
Entry DateJun 28 2007 5:16PM
Last ModifiedMar 1 2012 5:34PM
CommentMembers of this protein family are mycothiol-dependent formaldehyde dehydrogenase (EC This protein is found, so far, only in the Actinobacteria (Mycobacterium sp., Streptomyces sp., Corynebacterium sp., and related species), where mycothione replaces glutathione.
ReferencesRN [1] RM PMID:9202149 RT Mycothiol, 1-O-(2'-[N-acetyl-L-cysteinyl]amido-2'-deoxy-alpha-D-glucopyranosyl)-D- myo-inositol, is the factor of NAD/factor-dependent formaldehyde dehydrogenase. RA Misset-Smits M, van Ophem PW, Sakuda S, Duine JA RL FEBS Lett. 1997 Jun 9;409(2):221-2.
Genome PropertyGenProp0923: mycothiol system (HMM)