| Accession | TIGR03450 |
| Name | mycothiol_INO1 |
| Function | inositol 1-phosphate synthase |
| Trusted Cutoff | 638.00 |
| Domain Trusted Cutoff | 638.00 |
| Noise Cutoff | 582.40 |
| Domain Noise Cutoff | 582.40 |
| Isology Type | equivalog |
| EC Number | 5.5.1.- |
| HMM Length | 355 |
| Author | Haft DH |
| Entry Date | Jun 28 2007 3:49PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This enzyme, inositol 1-phosphate synthase as found in Actinobacteria, produces an essential precursor for several different products, including mycothiol, which is a glutathione analog, and phosphatidylinositol, which is a phospholipid. |
| References | RN [1]
RM PMID:10448034
RT Identification of the INO1 gene of Mycobacterium tuberculosis H37Rv reveals a novel class of inositol-1-phosphate synthase enzyme.
RA Bachhawat N, Mande SC
RL J Mol Biol. 1999 Aug 20;291(3):531-6.
RN [2]
RM PMID:12005437
RT Crystal structure of inositol 1-phosphate synthase from Mycobacterium tuberculosis, a key enzyme in phosphatidylinositol synthesis.
RA Norman RA, McAlister MS, Murray-Rust J, Movahedzadeh F, Stoker NG, McDonald NQ
RL Structure. 2002 Mar;10(3):393-402. |
