HMM Summary Page: TIGR03450

Functioninositol 1-phosphate synthase
Trusted Cutoff638.00
Domain Trusted Cutoff638.00
Noise Cutoff582.40
Domain Noise Cutoff582.40
Isology Typeequivalog
EC Number5.5.1.-
HMM Length355
AuthorHaft DH
Entry DateJun 28 2007 3:49PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme, inositol 1-phosphate synthase as found in Actinobacteria, produces an essential precursor for several different products, including mycothiol, which is a glutathione analog, and phosphatidylinositol, which is a phospholipid.
ReferencesRN [1] RM PMID:10448034 RT Identification of the INO1 gene of Mycobacterium tuberculosis H37Rv reveals a novel class of inositol-1-phosphate synthase enzyme. RA Bachhawat N, Mande SC RL J Mol Biol. 1999 Aug 20;291(3):531-6. RN [2] RM PMID:12005437 RT Crystal structure of inositol 1-phosphate synthase from Mycobacterium tuberculosis, a key enzyme in phosphatidylinositol synthesis. RA Norman RA, McAlister MS, Murray-Rust J, Movahedzadeh F, Stoker NG, McDonald NQ RL Structure. 2002 Mar;10(3):393-402.