HMM Summary Page: TIGR03447

Functioncysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase
Gene SymbolmshC
Trusted Cutoff485.10
Domain Trusted Cutoff485.10
Noise Cutoff427.15
Domain Noise Cutoff427.15
Isology Typeequivalog
EC Number6.3.1.13
HMM Length411
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryGlutathione and analogs
Gene Ontology TermGO:0010125: mycothiol biosynthetic process biological_process
AuthorHaft DH
Entry DateJun 28 2007 8:58AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are MshC, l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, an enzyme that uses ATP to ligate a Cys residue to a mycothiol precursor molecule, in the second to last step in mycothiol biosynthesis. This enzyme shows considerable homology to Cys--tRNA ligases, and many instances are misannotated as such. Mycothiol is found in Mycobacterium tuberculosis, Corynebacterium glutamicum, Streptomyces coelicolor, and various other members of the Actinobacteria. Mycothiol is an analog to glutathione.
ReferencesRN [1] RM PMID:16674910 RT A coupled spectrophotometric assay for l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase and its application for inhibitor screening. RA Newton GL, Ta P, Sareen D, Fahey RC RL Anal Biochem. 2006 Jun 15;353(2):167-73.
Genome PropertyGenProp0753: mycothiol biosynthesis (HMM)