| Accession | TIGR03447 |
| Name | mycothiol_MshC |
| Function | cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase |
| Gene Symbol | mshC |
| Trusted Cutoff | 485.10 |
| Domain Trusted Cutoff | 485.10 |
| Noise Cutoff | 427.15 |
| Domain Noise Cutoff | 427.15 |
| Isology Type | equivalog |
| EC Number | 6.3.1.13 |
| HMM Length | 411 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Glutathione and analogs |
| Gene Ontology Term | GO:0010125: mycothiol biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Jun 28 2007 8:58AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this protein family are MshC, l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, an enzyme that uses ATP to ligate a Cys residue to a mycothiol precursor molecule, in the second to last step in mycothiol biosynthesis. This enzyme shows considerable homology to Cys--tRNA ligases, and many instances are misannotated as such. Mycothiol is found in Mycobacterium tuberculosis, Corynebacterium glutamicum, Streptomyces coelicolor, and various other members of the Actinobacteria. Mycothiol is an analog to glutathione. |
| References | RN [1]
RM PMID:16674910
RT A coupled spectrophotometric assay for l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase and its application for inhibitor screening.
RA Newton GL, Ta P, Sareen D, Fahey RC
RL Anal Biochem. 2006 Jun 15;353(2):167-73. |
| Genome Property | GenProp0753: mycothiol biosynthesis (HMM) |
