HMM Summary Page: TIGR03446

Functionmycothiol conjugate amidase Mca
Gene Symbolmca
Trusted Cutoff277.15
Domain Trusted Cutoff277.15
Noise Cutoff227.90
Domain Noise Cutoff227.90
Isology Typeequivalog
HMM Length283
Mainrole CategoryCellular processes
Subrole CategoryDetoxification
AuthorHaft DH
Entry DateJun 27 2007 4:00PM
Last ModifiedFeb 14 2011 3:27PM
CommentMycobacterium tuberculosis, Corynebacterium glutamicum, and related species use the thiol mycothiol in place of glutathione. This enzyme, homologous to the (dispensible) MshB enzyme of mycothiol biosynthesis, is described as an amidase that acts on conjugates to mycothiol. It is a detoxification enzyme.
ReferencesRN [1] RM PMID:14556638 RT Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase. RA Steffek M, Newton GL, Av-Gay Y, Fahey RC RL Biochemistry. 2003 Oct 21;42(41):12067-76.
Genome PropertyGenProp0923: mycothiol system (HMM)