HMM Summary Page: TIGR03445

FunctionN-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
Gene SymbolmshB
Trusted Cutoff224.35
Domain Trusted Cutoff224.35
Noise Cutoff203.00
Domain Noise Cutoff203.00
Isology Typeequivalog
EC Number3.5.1.103
HMM Length284
Gene Ontology TermGO:0010125: mycothiol biosynthetic process biological_process
AuthorHaft DH
Entry DateJun 27 2007 3:33PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase, also called 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, the MshB protein of mycothiol biosynthesis in Mycobacterium tuberculosis and related species.
ReferencesRN [1] RM PMID:16630724 RT Purification and characterization of Mycobacterium tuberculosis 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, MshB, a mycothiol biosynthetic enzyme. RA Newton GL, Ko M, Ta P, Av-Gay Y, Fahey RC RL Protein Expr Purif. 2006 Jun;47(2):542-50. RN [2] RM PMID:11092856 RT N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis. RA Newton GL, Av-Gay Y, Fahey RC RL J Bacteriol. 2000 Dec;182(24):6958-63.
Genome PropertyGenProp0753: mycothiol biosynthesis (HMM)