HMM Summary Page: TIGR03430

Functiontryptophan dimethylallyltransferase
Gene SymboldmaW
Trusted Cutoff740.75
Domain Trusted Cutoff740.75
Noise Cutoff353.75
Domain Noise Cutoff353.75
Isology Typeequivalog
EC Number2.5.1.34
HMM Length419
AuthorHaft DH, Fedorova N
Entry DateJun 14 2007 9:09AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are the enzyme tryptophan dimethylallyltransferase (EC, a distinct clade within a larger group of aromatic prenyltransferases that may act on on trp-containing cyclic dipeptides, or on tyrosine or other related substrates. Tryptophan dimethylallyltransferase and related enzymes typically are of fungal origin are involved in the biosynthesis of secondary metabolites such as ergot alkaloids.
ReferencesRN [1] RM PMID:7488077 RT The Claviceps purpurea gene encoding dimethylallyltryptophan synthase, the committed step for ergot alkaloid biosynthesis. RA Tsai HF, Wang H, Gebler JC, Poulter CD, Schardl CL RL Biochem Biophys Res Commun. 1995 Nov 2;216(1):119-25.