HMM Summary Page: TIGR03429

Functionaromatic prenyltransferase, DMATS type
Trusted Cutoff163.85
Domain Trusted Cutoff163.85
Noise Cutoff69.85
Domain Noise Cutoff69.85
Isology Typesubfamily
EC Number2.5.-.-
HMM Length408
AuthorHaft DH, Fedorova N
Entry DateJun 13 2007 4:31PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are mostly fungal enzymes of secondary metabolite production. Characterized or partially characterized members include several examples of dimethylallyltryptophan synthase, a brevianamide F prenyltransferase, LtxC from lyngbyatoxin biosynthesis, and a probable dimethylallyl tyrosine synthase.
ReferencesRN [1] RM PMID:7488077 RT The Claviceps purpurea gene encoding dimethylallyltryptophan synthase, the committed step for ergot alkaloid biosynthesis. RA Tsai HF, Wang H, Gebler JC, Poulter CD, Schardl CL RL Biochem Biophys Res Commun. 1995 Nov 2;216(1):119-25. RN [2] RM PMID:14732265 RT The determinant step in ergot alkaloid biosynthesis by an endophyte of perennial ryegrass. RA Wang J, Machado C, Panaccione DG, Tsai HF, Schardl CL RL Fungal Genet Biol. 2004 RN [3] RM PMID:16000710 RT Overproduction, purification and characterization of FtmPT1, a brevianamide F prenyltransferase from Aspergillus fumigatus. RA Grundmann A, Li SM RL Microbiology. 2005 Jul;151(Pt 7):2199-207.Feb;41(2):189-98.