HMM Summary Page: TIGR03426

Functionrod shape-determining protein MreD
Gene SymbolmreD
Trusted Cutoff34.85
Domain Trusted Cutoff34.85
Noise Cutoff27.15
Domain Noise Cutoff27.15
Isology Typeequivalog
HMM Length154
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of murein sacculus and peptidoglycan
Gene Ontology TermGO:0003674: molecular_function molecular_function
GO:0008360: regulation of cell shape biological_process
AuthorHaft DH
Entry DateJun 12 2007 2:46PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are the MreD protein of bacterial cell shape determination. Most rod-shaped bacteria depend on MreB and RodA to achieve either a rod shape or some other non-spherical morphology such as coil or stalk formation. MreD is encoded in an operon with MreB, and often with RodA and PBP-2 as well. It is highly hydrophobic (therefore somewhat low-complexity) and highly divergent, and therefore sometimes tricky to discover by homology, but this model finds most examples.
Genome PropertyGenProp0166: mreBCD system (HMM)