| Accession | TIGR03423 |
| Name | pbp2_mrdA |
| Function | penicillin-binding protein 2 |
| Gene Symbol | mrdA |
| Trusted Cutoff | 455.00 |
| Domain Trusted Cutoff | 455.00 |
| Noise Cutoff | 390.25 |
| Domain Noise Cutoff | 390.25 |
| Isology Type | equivalog |
| HMM Length | 593 |
| Mainrole Category | Cell envelope |
| Subrole Category | Biosynthesis and degradation of murein sacculus and peptidoglycan |
| Gene Ontology Term | GO:0003824: catalytic activity molecular_function |
| | GO:0009252: peptidoglycan biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Jun 11 2007 11:12PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). |
| References | RN [1]
RM PMID:2644207
RT Nucleotide sequence of the rodA gene, responsible for the rod shape of Escherichia coli: rodA and the pbpA gene, encoding penicillin-binding protein 2, constitute the rodA operon.
RA Matsuzawa H, Asoh S, Kunai K, Muraiso K, Takasuga A, Ohta T
RL J Bacteriol. 1989 Jan;171(1):558-60. |
| Genome Property | GenProp0166: mreBCD system (HMM) |
