HMM Summary Page: TIGR03423

Functionpenicillin-binding protein 2
Gene SymbolmrdA
Trusted Cutoff455.00
Domain Trusted Cutoff455.00
Noise Cutoff390.25
Domain Noise Cutoff390.25
Isology Typeequivalog
HMM Length593
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of murein sacculus and peptidoglycan
Gene Ontology TermGO:0003824: catalytic activity molecular_function
GO:0009252: peptidoglycan biosynthetic process biological_process
AuthorHaft DH
Entry DateJun 11 2007 11:12PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape).
ReferencesRN [1] RM PMID:2644207 RT Nucleotide sequence of the rodA gene, responsible for the rod shape of Escherichia coli: rodA and the pbpA gene, encoding penicillin-binding protein 2, constitute the rodA operon. RA Matsuzawa H, Asoh S, Kunai K, Muraiso K, Takasuga A, Ohta T RL J Bacteriol. 1989 Jan;171(1):558-60.
Genome PropertyGenProp0166: mreBCD system (HMM)