| Accession | TIGR03421 |
| Name | FeS_CyaY |
| Function | iron donor protein CyaY |
| Gene Symbol | cyaY |
| Trusted Cutoff | 53.25 |
| Domain Trusted Cutoff | 53.25 |
| Noise Cutoff | 47.80 |
| Domain Noise Cutoff | 47.80 |
| Isology Type | equivalog |
| HMM Length | 104 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Other |
| Gene Ontology Term | GO:0005506: iron ion binding molecular_function |
| | GO:0016226: iron-sulfur cluster assembly biological_process |
| Author | Haft DH |
| Entry Date | Jun 7 2007 4:03PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this protein family are the iron-sulfur cluster (FeS) metabolism protein CyaY, a homolog of eukaryotic frataxin. ISC is one of several bacterial systems for FeS assembly; we find by Partial Phylogenetic Profiling vs. the ISC system that CyaY most like work with the ISC system for FeS cluster biosynthesis. A study of of cyaY mutants in Salmonella enterica bears this out. Although the trusted cutoff is set low enough to include eukaryotic frataxin sequences, a narrower, exception-type model (TIGR03421) identifies identifies members of that specific set. |
| References | RN [1]
RM PMID:16603772
RT Iron-sulfur cluster biosynthesis: characterization of Escherichia coli CYaY as an iron donor for the assembly of [2Fe-2S] clusters in the scaffold IscU.
RA Layer G, Ollagnier-de Choudens S, Sanakis Y, Fontecave M
RL J Biol Chem. 2006 Jun 16;281(24):16256-63.
RN [2]
RM PMID:16428423
RT Salmonella enterica strains lacking the frataxin homolog CyaY show defects in Fe-S cluster metabolism in vivo.
RA Vivas E, Skovran E, Downs DM
RL J Bacteriol. 2006 Feb;188(3):1175-9.
RN [3]
RM PMID: 16930487
RT Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic.
RA Haft DH, Paulsen IT, Ward N, Selengut JD
RL BMC Biol. 2006 Aug 24;4:29.
DR HAMAP; MF_00142; 127 of 129 |
| Genome Property | GenProp0138: iron-sulfur cluster assembly iscSUA-hscBA-fdx system (HMM) |
