HMM Summary Page: TIGR03421

Functioniron donor protein CyaY
Gene SymbolcyaY
Trusted Cutoff53.25
Domain Trusted Cutoff53.25
Noise Cutoff47.80
Domain Noise Cutoff47.80
Isology Typeequivalog
HMM Length104
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryOther
Gene Ontology TermGO:0005506: iron ion binding molecular_function
GO:0016226: iron-sulfur cluster assembly biological_process
AuthorHaft DH
Entry DateJun 7 2007 4:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are the iron-sulfur cluster (FeS) metabolism protein CyaY, a homolog of eukaryotic frataxin. ISC is one of several bacterial systems for FeS assembly; we find by Partial Phylogenetic Profiling vs. the ISC system that CyaY most like work with the ISC system for FeS cluster biosynthesis. A study of of cyaY mutants in Salmonella enterica bears this out. Although the trusted cutoff is set low enough to include eukaryotic frataxin sequences, a narrower, exception-type model (TIGR03421) identifies identifies members of that specific set.
ReferencesRN [1] RM PMID:16603772 RT Iron-sulfur cluster biosynthesis: characterization of Escherichia coli CYaY as an iron donor for the assembly of [2Fe-2S] clusters in the scaffold IscU. RA Layer G, Ollagnier-de Choudens S, Sanakis Y, Fontecave M RL J Biol Chem. 2006 Jun 16;281(24):16256-63. RN [2] RM PMID:16428423 RT Salmonella enterica strains lacking the frataxin homolog CyaY show defects in Fe-S cluster metabolism in vivo. RA Vivas E, Skovran E, Downs DM RL J Bacteriol. 2006 Feb;188(3):1175-9. RN [3] RM PMID: 16930487 RT Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic. RA Haft DH, Paulsen IT, Ward N, Selengut JD RL BMC Biol. 2006 Aug 24;4:29. DR HAMAP; MF_00142; 127 of 129
Genome PropertyGenProp0138: iron-sulfur cluster assembly iscSUA-hscBA-fdx system (HMM)