| Accession | TIGR03420 |
| Name | DnaA_homol_Hda |
| Function | DnaA regulatory inactivator Hda |
| Gene Symbol | hda |
| Trusted Cutoff | 194.80 |
| Domain Trusted Cutoff | 194.80 |
| Noise Cutoff | 128.10 |
| Domain Noise Cutoff | 128.10 |
| Isology Type | equivalog |
| HMM Length | 226 |
| Mainrole Category | DNA metabolism |
| Subrole Category | DNA replication, recombination, and repair |
| Gene Ontology Term | GO:0016818: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides molecular_function |
| | GO:0032297: negative regulation of DNA-dependent DNA replication initiation biological_process |
| Author | Haft DH |
| Entry Date | Jun 6 2007 10:51AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this protein family are Hda (Homologous to DnaA). These proteins are about half the length of DnaA and homologous over length of Hda. In the model species Escherichia coli, the initiation of DNA replication requires DnaA bound to ATP rather than ADP; Hda helps facilitate the conversion of DnaA-ATP to DnaA-ADP. |
| References | RN [1]
RM 16882985
RT Hda-mediated inactivation of the DnaA protein and dnaA gene autoregulation act in concert to ensure homeostatic maintenance of the Escherichia coli chromosome.
RA Riber L, Olsson JA, Jensen RB, Skovgaard O, Dasgupta S, Marinus MG, Løbner-Olesen A.
RL Genes Dev. 2006 Aug 1;20(15):2121-34 |
