HMM Summary Page: TIGR03420

FunctionDnaA regulatory inactivator Hda
Gene Symbolhda
Trusted Cutoff194.80
Domain Trusted Cutoff194.80
Noise Cutoff128.10
Domain Noise Cutoff128.10
Isology Typeequivalog
HMM Length226
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0016818: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides molecular_function
GO:0032297: negative regulation of DNA-dependent DNA replication initiation biological_process
AuthorHaft DH
Entry DateJun 6 2007 10:51AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are Hda (Homologous to DnaA). These proteins are about half the length of DnaA and homologous over length of Hda. In the model species Escherichia coli, the initiation of DNA replication requires DnaA bound to ATP rather than ADP; Hda helps facilitate the conversion of DnaA-ATP to DnaA-ADP.
ReferencesRN [1] RM 16882985 RT Hda-mediated inactivation of the DnaA protein and dnaA gene autoregulation act in concert to ensure homeostatic maintenance of the Escherichia coli chromosome. RA Riber L, Olsson JA, Jensen RB, Skovgaard O, Dasgupta S, Marinus MG, LÝbner-Olesen A. RL Genes Dev. 2006 Aug 1;20(15):2121-34