HMM Summary Page: TIGR03413

Functionhydroxyacylglutathione hydrolase
Gene SymbolgloB
Trusted Cutoff200.80
Domain Trusted Cutoff200.80
Noise Cutoff133.00
Domain Noise Cutoff133.00
Isology Typeequivalog
EC Number3.1.2.6
HMM Length248
Mainrole CategoryCellular processes
Subrole CategoryDetoxification
Gene Ontology TermGO:0004416: hydroxyacylglutathione hydrolase activity molecular_function
GO:0019243: methylglyoxal catabolic process to D-lactate biological_process
AuthorHaft DH
Entry DateMay 16 2007 2:25PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are hydroxyacylglutathione hydrolase, a detoxification enzyme known as glyoxalase II. It follows lactoylglutathione lyase, or glyoxalase I, and acts to remove the toxic metabolite methylglyoxal and related compounds. This protein belongs to the broader metallo-beta-lactamase family (PF00753).
ReferencesRN [1] RM PMID: 17196158 RT Escherichia coli glyoxalase II is a binuclear zinc-dependent metalloenzyme. RA O'Young J, Sukdeo N, Honek JF RL Arch Biochem Biophys. 2007 Mar 1;459(1):20-6. RN [2] RM PMID: 10882093 RT Detection and characterisation of the genes encoding glyoxalase I and II from Neisseria meningitidis. RA Kizil G, Wilks K, Wells D, Ala'Aldeen DA RL J Med Microbiol. 2000 Jul;49(7):669-73.
Genome PropertyGenProp0744: glyoxalase pathway, glutathione dependent (HMM)