HMM Summary Page: TIGR03407

Functionurea ABC transporter, urea binding protein
Gene SymbolurtA
Trusted Cutoff492.75
Domain Trusted Cutoff492.75
Noise Cutoff378.35
Domain Noise Cutoff378.35
Isology Typeexception
HMM Length361
Mainrole CategoryTransport and binding proteins
Subrole CategoryAmino acids, peptides and amines
Gene Ontology TermGO:0015840: urea transport biological_process
GO:0030288: outer membrane-bounded periplasmic space cellular_component
GO:0033219: urea binding molecular_function
GO:0033221: urea-transporting ATPase activity molecular_function
GO:0055052: ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing cellular_component
AuthorHaft DH
Entry DateMay 11 2007 2:58PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are ABC transporter substrate-binding proteins associated with urea transport and metabolism. This protein is found in a conserved five-gene transport operon typically found adjacent to urease genes. It was shown in Cyanobacteria that disruption leads to the loss of high-affinity urea transport activity. Members of this protein family tend to have the twin-arginine signal for Sec-independent transport across the plasma membrane.
ReferencesRN [1] RM PMID: 11929526 RT An ABC-type, high-affinity urea permease identified in cyanobacteria. RA Valladares A, Montesinos ML, Herrero A, Flores E RL Mol Microbiol. 2002 Feb;43(3):703-15.
Genome PropertyGenProp0743: urea ABC transporter UrtABCDE (HMM)