HMM Summary Page: TIGR03403

Functioncysteine desulfurase, NifS family
Gene SymbolnifS
Trusted Cutoff587.70
Domain Trusted Cutoff587.70
Noise Cutoff446.30
Domain Noise Cutoff446.30
Isology Typeequivalog
EC Number2.8.1.7
HMM Length382
AuthorHaft DH
Entry DateMay 2 2007 5:18PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are the NifS-like cysteine desulfurase of the epsilon division of the Proteobacteria, similar to the NifS protein of nitrogen-fixing bacteria. Like NifS, and unlike IscS, this protein is found as part of a system of just two proteins, a cysteine desulfurase and a scaffold, for iron-sulfur cluster biosynthesis. This protein is called NifS by Olsen, et al. (PMID:11123951), so we use this designation.
ReferencesRN [1] RM PMID: 11123951 RT Characterization of the NifU and NifS Fe-S cluster formation proteins essential for viability in Helicobacter pylori. RA Olson JW, Agar JN, Johnson MK, Maier RJ RL Biochemistry. 2000 Dec 26;39(51):16213-9.
Genome PropertyGenProp0742: iron-sulfur cluster assembly NIF system (HMM)