HMM Summary Page: TIGR03402

Functioncysteine desulfurase NifS
Gene SymbolnifS
Trusted Cutoff530.75
Domain Trusted Cutoff530.75
Noise Cutoff445.25
Domain Noise Cutoff445.25
Isology Typeequivalog
EC Number2.8.1.7
HMM Length379
AuthorHaft DH
Entry DateMay 1 2007 3:47PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are NifS, one of several related families of cysteine desulfurase involved in iron-sulfur (FeS) cluster biosynthesis. NifS is part of the NIF system, usually associated with other nif genes involved in nitrogenase expression and nitrogen fixation. The protein family is given a fairly broad interpretation here. It includes a clade nearly always found in extended nitrogen fixation genomic regions, plus a second clade more closely related to the first than to IscS and also part of NifS-like/NifU-like systems. This model does not extend to a more distantly clade found in the epsilon proteobacteria such as Helicobacter pylori, also named NifS in the literature, built instead in TIGR03403.
ReferencesRN [1] RM PMID: 10639125 RT NifS-directed assembly of a transient [2Fe-2S] cluster within the NifU protein. RA Yuvaniyama P, Agar JN, Cash VL, Johnson MK, Dean DR RL Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):599-604.RN [2] RM PMID: 15667274 RT NifU and NifS are required for the maturation of nitrogenase and cannot replace the function of isc-gene products in Azotobacter vinelandii. RA Johnson DC, Dos Santos PC, Dean DR RL Biochem Soc Trans. 2005 Feb;33(Pt 1):90-3.
Genome PropertyGenProp0742: iron-sulfur cluster assembly NIF system (HMM)