HMM Summary Page: TIGR03401

FunctionHD domain protein, cyanamide hydratase family
Trusted Cutoff109.85
Domain Trusted Cutoff109.85
Noise Cutoff78.85
Domain Noise Cutoff78.85
Isology Typesubfamily
EC Number4.2.1.-
HMM Length228
AuthorHaft DH
Entry DateMay 1 2007 9:07AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are known, so far, in the Ascomycota, a branch of the Fungi, and contain an HD domain (PF01966), found typically in various metal-dependent phosphohydrolases. The only characterized member of this family, from the soil fungus Myrothecium verrucaria, is cyanamide hydratase (EC, a zinc-containing homohexamer that adds water to the fertilizer cyanamide (NCNH2), a nitrile compound, to produce urea (NH2-CO-NH2). Homologs are likely to be nitrile hydratases.
ReferencesRN [1] RM PMID: 2034671 RT Isolation and properties of a nitrile hydratase from the soil fungus Myrothecium verrucaria that is highly specific for the fertilizer cyanamide and cloning of its gene. RA Maier-Greiner UH, Obermaier-Skrobranek BM, Estermaier LM, Kammerloher W, Freund C, Wulfing C, Burkert UI, Matern DH, Breuer M, Eulitz M, et al. RL Proc Natl Acad Sci U S A. 1991 May 15;88(10):4260-4.