| Accession | TIGR03401 |
| Name | cyanamide_fam |
| Function | HD domain protein, cyanamide hydratase family |
| Trusted Cutoff | 109.85 |
| Domain Trusted Cutoff | 109.85 |
| Noise Cutoff | 78.85 |
| Domain Noise Cutoff | 78.85 |
| Isology Type | subfamily |
| EC Number | 4.2.1.- |
| HMM Length | 228 |
| Author | Haft DH |
| Entry Date | May 1 2007 9:07AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this protein family are known, so far, in the Ascomycota, a branch of the Fungi, and contain an HD domain (PF01966), found typically in various metal-dependent phosphohydrolases. The only characterized member of this family, from the soil fungus Myrothecium verrucaria, is cyanamide hydratase (EC 4.2.1.69), a zinc-containing homohexamer that adds water to the fertilizer cyanamide (NCNH2), a nitrile compound, to produce urea (NH2-CO-NH2). Homologs are likely to be nitrile hydratases. |
| References | RN [1]
RM PMID: 2034671
RT Isolation and properties of a nitrile hydratase from the soil fungus Myrothecium verrucaria that is highly specific for the fertilizer cyanamide and cloning of its gene.
RA Maier-Greiner UH, Obermaier-Skrobranek BM, Estermaier LM, Kammerloher W, Freund C, Wulfing C, Burkert UI, Matern DH, Breuer M, Eulitz M, et al.
RL Proc Natl Acad Sci U S A. 1991 May 15;88(10):4260-4. |
