HMM Summary Page: TIGR03398

Functionphospholipase C accessory protein PlcR
Gene SymbolplcR
Trusted Cutoff99.10
Domain Trusted Cutoff99.10
Noise Cutoff98.60
Domain Noise Cutoff98.60
Isology Typeequivalog
HMM Length141
AuthorHaft DH
Entry DateApr 26 2007 1:45PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe class of microbial phosphocholine-preferring phospholipase C enzymes described by model TIGR03396 has two members in Pseudomonas aeruginosa, one of which (PlcH) is hemolytic and can hydrolyzes sphingomyelin as well as phosphatidylcholine. This model describes PlcR, an accessory protein for PlcH with which it forms a heterodimer. The member of the family from P. aeruginosa, although not the members from various Burkholderia species, is encoded immediately downstream of phospholipase C.
ReferencesRN [1] RM PMID: 12410824 RT A novel class of microbial phosphocholine-specific phospholipases C. RA Stonehouse MJ, Cota-Gomez A, Parker SK, Martin WE, Hankin JA, Murphy RC, Chen W, Lim KB, Hackett M, Vasil AI, Vasil ML RL Mol Microbiol. 2002 Nov;46(3):661-76.