HMM Summary Page: TIGR03395

Functionsphingomyelin phosphodiesterase
Gene Symbolsph
Trusted Cutoff248.20
Domain Trusted Cutoff248.20
Noise Cutoff178.80
Domain Noise Cutoff178.80
Isology Typeequivalog
EC Number3.1.4.12
HMM Length286
Mainrole CategoryCellular processes
Subrole CategoryPathogenesis
Gene Ontology TermGO:0004767: sphingomyelin phosphodiesterase activity molecular_function
AuthorHaft DH
Entry DateApr 25 2007 2:58PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are bacterial proteins that act as sphingomyelin phosphodiesterase (EC, also called sphingomyelinase. Some members of this family have been shown to act as hemolysins.
ReferencesRM PMID: 2163985 RT Molecular analysis of a sphingomyelinase C gene from Leptospira interrogans serovar hardjo. RA Segers RP, van der Drift A, de Nijs A, Corcione P, van der Zeijst BA, Gaastra W RL Infect Immun. 1990 Jul;58(7):2177-85.