HMM Summary Page: TIGR03393

Functionindolepyruvate decarboxylase
Gene SymbolipdC
Trusted Cutoff946.00
Domain Trusted Cutoff946.00
Noise Cutoff696.00
Domain Noise Cutoff696.00
Isology Typeequivalog
EC Number4.1.1.74
HMM Length539
Mainrole CategoryCentral intermediary metabolism
Subrole CategoryOther
Gene Ontology TermGO:0009684: indoleacetic acid biosynthetic process biological_process
GO:0047434: indolepyruvate decarboxylase activity molecular_function
AuthorHaft DH
Entry DateApr 25 2007 10:02AM
Last ModifiedFeb 14 2011 3:27PM
CommentA family of closely related, thiamine pyrophosphate-dependent enzymes includes indolepyruvate decarboxylase (EC, phenylpyruvate decarboxylase (EC, pyruvate decarboxylase (EC, branched-chain alpha-ketoacid decarboxylase, etc.. Members of this group of homologs may overlap in specificity. Within the larger family, this model represents a clade of bacterial indolepyruvate decarboxylases, part of a pathway for biosynthesis of the plant hormone indole-3-acetic acid. Typically, these species interact with plants, as pathogens or as beneficial, root-associated bacteria.
ReferencesRN [1] RM PMID: 12752451 RT Crystal structure of thiamindiphosphate-dependent indolepyruvate decarboxylase from Enterobacter cloacae, an enzyme involved in the biosynthesis of the plant hormone indole-3-acetic acid. RA Schutz A, Sandalova T, Ricagno S, Hubner G, Konig S, Schneider G RL Eur J Biochem. 2003 May;270(10):2312-21.